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The introduction of liposomal and S-acetyl-glutathione formulations in the 2000s addressed the bioavailability problem that had limited oral supplementation since the 1960s

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showed that GLP-2 administered subcutaneously (s.c.) in doses ranging from 200, 400, and 800 g in healthy postmenopausal women dose-dependently reduced bone resorption (measured as CTX), while the bone formation (measured as osteocalcin) was unaffected (7)

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