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Storage Requirements: Unopened lyophilized AOD-9604 should be stored in a refrigerator at 2-8C (36-46F) and protected from light
Administered subcutaneously, its injectable form is rapidly absorbed and distributed to metabolically active tissues, where it specifically binds and inhibits NNMT catalytic activity without interfering with other enzymes in the nicotinamide pathway or NAD+ synthesis
However, one study on the treatment of children with methylmalonic acidemia and homocystinuria found oral hydroxocobalamine at 1 mg daily to be ineffective in reducing levels of homocysteine
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Dosing & Reconstitution Guide Educational guide for reconstitution and daily dosing Subcutaneous Protocol (4 mL = 12.5 mg/mL) Frequency: Inject once or twice daily subcutaneously
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