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And perhaps most importantly, recalibrate your tolerance expectations
No long-term human safety data: The absence of evidence of harm is not evidence of absence
Subtle conformational dynamics allow the C-terminus of GLP-1 to access the ECD binding site, and the ligand binding triggers further dissociation of the ECD from the TMD allowing the N-terminus of GLP-1 to enter the orthosteric pocket in the TMD and activate the receptor
doi: 10.1038/s41467-020-14959-w 5 ArvanitakisZ.CapuanoA
Chen BD, Zhao WC, Dong JD, Sima H
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