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Severe or prolonged B12 deficiency can lead to a range of neurological manifestations, including peripheral neuropathy, which may present as pain, paraesthesia (pins and needles), or altered sensation in the extremities

Practical checklist before considering use Dose: No validated human dosing exists

This near-parity is the basis for the model of ghkcu as a physiological copper shuttle rather than an inert chelator

The long-term effects, optimal dosing, and potential drug interactions are not fully understood

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