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When the tumor volume reached approximately 200 mm, the mice were intravenously administered with Cy7.5-labeled NP4 at a dosage of 2 mg/kg

The cancer cells were preincubated with NAC and subsequently treated with NP4 showed a reduced number of TNF- secreted from the macrophages, suggesting that macrophage activation is associated with the NP4-induced oxidative stress

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