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Some are fixable
10.1016/j.mgene.2020.100751 5
Oral platforms, implant concepts, cartridges, pens, and vial routes are all becoming part of the commercial discussion
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However, an uncontrolled increase in their concentrations leads to a chain of unwanted radical reactions that target the main biomolecules (DNA, RNA, lipids, and proteins) and alters key processes such as nucleic acid oxidation, lipid peroxidation, thereby contributing to the loss of cellular architecture, to impaired cell signalling and, ultimately, to cell death [25, 46]
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