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Upon digestion, amino acids and peptides activate calcium-sensing and G-protein-coupled receptors on intestinal L-cells

The key to carbs is portion control since many starchy foods are high in calories

Nausea, reduced appetite, and burping occur commonly with subcutaneous injections too, especially during the first few weeks of treatment or after a dose increase

Fermented foods, prebiotic foods, and polyphenol-rich foods may support gut microbiome health and indirectly enhance GLP-1 secretion

While both are manufactured by Eli Lilly and both activate the GLP-1 and GIP receptors, retatrutide is a triple agonist that also activates the glucagon receptor