Common side effects are usually mild to moderate and may include: Nausea Diarrhea Vomiting Stomach pain Redness at the injection site Suppressed appetite Weight loss Low blood sugar (particularly if combined with insulin therapy) Rare but serious side effects can include: Acute pancreatitis, Severe allergic reactions, Impaired kidney function, and Medullary thyroid carcinoma (MTC) Avoid this medication if you have a personal or family history of MTC or multiple endocrine neoplasia, or if you are allergic to dulaglutide
Tirzepatide (Mounjaro/Zepbound), Eli Lillys dual GLP-1 + GIP agonist, is already growing faster than semaglutide in the US
Many practitioners recommend starting at a low dose (100-250 mcg) and titrating up to reduce nausea severity
Of note, non-neuronal cells of various tissues and organ systems also synthesize and release acetylcholine, which then binds and stimulates cholinergic receptors on target cells (reviewed in 6)
If you notice symptoms such as a rash, itching, or trouble breathing, seek medical attention immediately