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If you experience numbness and weakness in your hand, consider seeing a doctor ASAP

Cell Communication and Signaling Research by Julianna Kardos et al., published in Cell Communication and Signaling

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Resveratrol, a polyphenolic stilbene, displays concentration-dependent biphasic actions, at low doses it can weakly mimic estrogenic effects via ER activation, whereas at higher pharmacologic concentrations it acts as an ER antagonist, inhibits aromatase transcription, and disrupts co-activator recruitment to the ER complex, thereby exerting anti-proliferative and pro-apoptotic effects in ER-positive breast cancer cells (192)