Lethale Akrodermatitis (LAD) All Inheritance: autosomal dominant (incomplete penetrance)

Inheritance: autosomal dominant (incomplete penetrance)

Die betroffenen Welpen müssen oft aufgrund schwerer Symptome eingeschläfert werden

muscles and skin

The amount and distribution of pheomelanin may vary between individual dogs and between breeds

Afghan hounds and Eurasier

Lethale Akrodermatitis (LAD) All Inheritance: autosomal dominant (incomplete penetrance)Lethal acrodermatitis (LAD) is characterized by poor growth, immune deficiency, and skin lesions, especially at the paws. Affected puppies show characteristic skin lesions on the feet and on the face, diarrhoea, bronchopneumonia, and a failure to thrive. Coat color can be diluted in pigmented skin areas. LAD affected dogs are immunodeficient and frequently suffer from skin infections with Malassezia or Candida. They grow slower than their non affected