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Mutation: CDH23 gene
therefore its excess in urine forms crystals that lead to formation of cystine stones in kidney or bladder
such as vaccination or viral infection
In the chronic type
at/science/dla-variety-or-not/
X-chromosomal Myotubuläre Myopathie (XL-MTM) - Rottweiler Rassebestimmung Mutation: CDH23 geneMyotubular myopathy is a X linked recessive disorder. Affected infant male puppies show signs of facial, axial and proximal neuromuscular weakness with tetraparesis, difficulty holding the head up and a dropped jaw, including hypotonia and areflexia leading to respiratory insufficiency and death within 2 weeks. The symptoms usually occur postnatal and progress very quickly. The affected male puppies have to be euthanised due to progressive symptoms.
